GSK484

GSK484 hydrochloride is a selective and reversible peptidylarginine deiminase 4 (PAD4) inhibitor. GSK484 hydrochloride demonstrates high affinity binding to PAD4 with IC50s of 50 nM in the absence of Calcium.


Cat. No.: EX-A2392	Purity: >98%

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	585	In-stock
250mg	850	In-stock
500mg	950	In-stock
1g	1450	In-stock
5g	4850	In-stock
10g	7760	In-stock

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Synonyms	GSK484 hydrochloride
CAS No.	1652591-81-5
Purity	>98%
Formula	C27H32ClN5O3
Mol Weight	510.028
Appearance	white to off-white powder
Solubility	Soluble in DMSO/H2O
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Lewis HD, et al. Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation. Nat Chem Biol. 2015 Mar;11(3):189-91. [2]. Cedervall J, et al. Pharmacological targeting of peptidylarginine deiminase 4 prevents cancer-associated kidney injury in mice. Oncoimmunology. 2017 Apr 20;6(8):e1320009.
CoA	CoA of GSK484

Smiles:	Cl.COC1=C2N(C)C(=NC2=CC(=C1)C(=O)N1CC[C@@H](O)[C@@H](N)C1)C1=CC2=C(C=CC=C2)N1CC1CC1


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