AG-881

AG-881, Vorasidenib, is a potent and selective orally available inhibitor of mutated forms of both isocitrate dehydrogenase type 1 (IDH1, IDH1 [NADP+] soluble) in the cytoplasm and type 2 (IDH2, isocitrate dehydrogenase [NADP+], mitochondrial) in the mitochondria, with potential antineoplastic activity. AG-881 specifically inhibits mutant forms of IDH1 and IDH2, thereby inhibiting the formation of the oncometabolite 2-hydroxyglutarate (2HG) from alpha-ketoglutarate (a-KG). This prevents 2HG-mediated signaling and leads to both an induction of cellular differentiation and an inhibition of cellular proliferation in tumor cells expressing IDH mutations.


Cat. No.: EX-A2574	Purity: >98%

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
250mg	600	In-stock
500mg	780	In-stock
1g	1000	In-stock
5g	3200	In-stock
10g	4750	In-stock
25g	9760	In-stock

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Synonyms	Vorasidenib
CAS No.	1644545-52-7
Purity	>98%
Formula	C14H13ClF6N6
Mol Weight	414.737
Appearance	solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Chen J, Yang J, Cao P. The Evolving Landscape in the Development of Isocitrate Dehydrogenase Mutant Inhibitors. Mini Rev Med Chem. 2016;16(16):1344-1358. Review. PubMed PMID: 27292784.
CoA	CoA of AG-881

Smiles:	C[C@@H](NC1=NC(N[C@H](C)C(F)(F)F)=NC(=N1)C1=NC(Cl)=CC=C1)C(F)(F)F


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