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Product Information:

MYK-461

MYK461, Mavacamten, is an orally active modulator of cardiac myosin, with IC50s of 490, 711 nM for bovine cardiac and human cardiac, respectively.

Cat. No.: EX-A2072    Purity: >98%
MYK-461
For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
100mg385In-stock
250mg485In-stock
500mg650In-stock
1g950In-stock
5g2450In-stock
10g3385In-stock


SynonymsMavacamten
Synonyms 2SAR439152
CAS No.1642288-47-8
Purity>98%
FormulaC15H19N3O2
Mol Weight273.3303
Appearancesolid powder
SolubilitySoluble in DMSO, not in water
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  [1]. Kawas RF, et al. A small-molecule modulator of cardiac myosin acts on multiple stages of the myosin chemomechanical cycle. J Biol Chem. 2017 Oct 6;292(40):16571-16577.

[2]. Stern JA, et al. A Small Molecule Inhibitor of Sarcomere Contractility Acutely Relieves Left Ventricular Outflow Tract Obstruction in Feline Hypertrophic Cardiomyopathy. PLoS One. 2016 Dec 14;11(12):e0168407.

[3]. Green EM, et al. A small-molecule inhibitor of sarcomere contractility suppresses hypertrophic cardiomyopathy in mice. Science. 2016 Feb 5;351(6273):617-21.
CoACoA of MYK-461
Smiles:CC(C)N1C(=O)NC(N[C@@H](C)C2=CC=CC=C2)=CC1=O

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