GSK481

GSK481 is a potent inhibitor of Receptor-interacting serine/threonine-protein kinase 1 (RIPK1 or RIP1; IC50 value 2.8 nM for inhibition of S166 phosphorylation of hWT RIP1) exhibiting a remarkable specificity over >450 other kinases. GSK'481 protects against TNF-induced inflammation and lethal shock.


Cat. No.: EX-A2322	Purity: >98%

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	875	In-stock
200mg	1185	In-stock
500mg	1785	In-stock

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Synonyms	GSK'481
CAS No.	1622849-58-4
Purity	>98%
Formula	C21H19N3O4
Mol Weight	377.3933
Appearance	solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. PA Harris, et al. DNA-Encoded Library Screening Identifies Benzo[b][1,4]oxazepin-4-ones as Highly Potent and Monoselective Receptor Interacting Protein 1 Kinase Inhibitors. J Med Chem. 2016 Mar 10;59(5):2163-78. [2]. P Geserick, et al. Absence of RIPK3 predicts necroptosis resistance in malignant melanoma. Cell Death Dis. 2015 Sep 10;6:e1884.
CoA	CoA of GSK481

Smiles:	CN1C2=CC=CC=C2OC[C@H](NC(=O)C2=NOC(CC3=CC=CC=C3)=C2)C1=O


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