GNE9605

GNE-9605 is a potent, orally active, selective Leucine-rich repeat kinase 2 (LRRK2) inhibitor with an IC50 value of 18.7 nM. GNE-9605 inhibits LRRK2 Ser1292 autophosphorylation. GNE-9605 can be used in research of Parkinson's disease (PD).


Cat. No.: EX-A2064	Purity: >98%

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	550	In-stock
250mg	750	In-stock
500mg	985	In-stock
1g	1285	In-stock
5g	4800	In-stock
10g	7200	In-stock

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Synonyms	GNE-9605
CAS No.	1536200-31-3
Purity	>98%
Formula	C17H20ClF4N7O
Mol Weight	449.834
Appearance	solid powder
Solubility	DMSO : >50 mg/mL
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Estrada AA, et, al. Discovery of highly potent, selective, and brain-penetrant aminopyrazole leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitors. J Med Chem. 2014 Feb 13;57(3):921-36. [2]. Kumar S, et, al. Exploring the focal role of LRRK2 kinase in Parkinson's disease. Environ Sci Pollut Res Int. 2022 May;29(22):32368-32382.
CoA	CoA of GNE9605

Smiles:	CNC1=NC(NC2=C(Cl)N(N=C2)[C@H]2CCN(C[C@@H]2F)C2COC2)=NC=C1C(F)(F)F


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