PFK-158

PFK-158 is a potent and selective PFKFB3 inhibitor with an IC50 value 137 nM. PFK-158 has broad anti-tumor activity. PFK-158 can also enhance Colistin's resistance to bacteria.


Cat. No.: EX-A2480	Purity: >98%

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
250mg	550	In-stock
500mg	795	In-stock
1g	1250	In-stock
1g	1880	In-stock
3g	2520	In-stock
5g	3800	In-stock

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CAS No.	1462249-75-7
Purity	>98%
Formula	C18H11F3N2O
Mol Weight	328.2879
Appearance	white to light yellow solid
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Mondal S, et al. Therapeutic targeting of PFKFB3 with a novel glycolytic inhibitor PFK158 promotes lipophagy and chemosensitivity in gynecologic cancers. Int J Cancer. 2019 Jan 1;144(1):178-189. [2]. Zhang Y, et al. Synergistic Effect of Colistin Combined with PFK-158 against Colistin-Resistant Enterobacteriaceae. Antimicrob Agents Chemother. 2019 Jun 24;63(7). pii: e00271-19. [3]. Pooran Chand, et al. Pfkfb3 inhibitor and methods of use as an anti-cancer therapeutic. WO2013148228A1.
CoA	CoA of PFK-158

Smiles:	FC(F)(F)C1=CC=C2C=CC(\C=C\C(=O)C3=CC=NC=C3)=NC2=C1


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