UAMC1110

UAMC1110 (SP-13786) is a novel, potent and highly selective inhibitor of fibroblast activation protein (FAP) with IC50 of 3.2 nM. UAMC1110 also inhibits prolyl oligopeptidase (PREP) with an IC50 of 1.8 μM.


Cat. No.: EX-A2803	Purity: >98%

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	485	In-stock
250mg	685	In-stock
500mg	885	In-stock
1g	1385	In-stock
5g	4285	In-stock
10g	6585	In-stock

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Synonyms	SP-13786
CAS No.	1448440-52-5
Purity	>98%
Formula	C17H14F2N4O2
Mol Weight	344.3155
Appearance	solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Jansen, Koen et al. Extended structure-activity relationship and pharmacokinetic investigation of (4-quinolinoyl)glycyl-2-cyanopyrrolidine inhibitors of fibroblast activation protein (FAP). Journal of medicinal chemistry vol. 57,7 (2014): 3053-74.
CoA	CoA of UAMC1110

Smiles:	FC1(F)C[C@@H](C#N)N(C1)C(=O)CNC(=O)C1=CC=NC2=CC=CC=C12


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