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Product Information:

PLX7904

PLX7904 (PB04) is a potent and selective BRAF inhibitor, with IC50 of appr 5 nM against BRAFV600E in mutant RAS expressing cells.

Cat. No.: EX-A2872    Purity: >98%
PLX7904
For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
100mg585In-stock
200mg785In-stock
500mg1085In-stock
1g1685In-stock
5g5895In-stock
10g8685In-stock


SynonymsPB04
CAS No.1393465-84-3
Purity>98%
FormulaC24H22F2N6O3S
Mol Weight512.532
Appearancesolid powder
SolubilitySoluble in DMSO
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Zhang C, et al. RAF inhibitors that evade paradoxical MAPK pathway activation. Nature. 2015 Oct 22;526(7574):583-586.

[2]. Basile KJ, et al. Inhibition of mutant BRAF splice variant signaling by next-generation, selective RAF inhibitors. Pigment Cell Melanoma Res. 2014 May;27(3):479-84

[3]. Le K, et al. Selective RAF inhibitor impairs ERK1/2 phosphorylation and growth in mutant NRAS, vemurafenib-resistant melanoma cells. Pigment Cell Melanoma Res. 2013 Jul;26(4):509-17

CoACoA of PLX7904
Smiles:CCN(C)S(=O)(=O)NC1=C(F)C(C(=O)C2=CNC3=NC=C(C=C23)C2=CN=C(N=C2)C2CC2)=C(F)C=C1

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