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Product Information:

Tropifexor

LJN452, also known as Tropifexor, is a highly potent agonist of FXR with an EC50 of 0.2 nM.

Cat. No.: EX-A1934    Purity: >98%
Tropifexor
For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
100mg550In-stock
250mg800In-stock
500mg1250In-stock
1g1850In-stock
5g5550In-stock
10g9525In-stock


SynonymsLJN452
CAS No.1383816-29-2
Purity>98%
FormulaC29H25F4N3O5S
Mol Weight603.585
Appearanceoff-white solid powder
SolubilityDMSO >50mg/mL
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Tully DC, et al. Discovery of Tropifexor (LJN452), a Highly Potent Non-bile Acid FXR Agonist for the Treatment of Cholestatic Liver Diseases and Nonalcoholic Steatohepatitis (NASH). J Med Chem. 2017 Dec 8.

CoACoA of Tropifexor
Smiles:OC(=O)C1=CC(F)=C2N=C(SC2=C1)N1[C@H]2CC[C@@H]1C[C@@H](C2)OCC1=C(ON=C1C1=C(OC(F)(F)F)C=CC=C1)C1CC1

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