C25-140

C25-140, a first-in-class, orally active, and fairly selective TRAF6-Ubc13 inhibitor, directly binds to TRAF6, and blocks the interaction of TRAF6 with Ubc13. C25-140 lowers TRAF6 activity, reduces NF-κB activation, and combats autoimmunity.


Cat. No.: EX-A2990	Purity: >98%

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
50mg	590	In-stock
100mg	850	In-stock
250mg	1350	In-stock
1g	2200	In-stock
5g	Get quote	Inquire

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CAS No.	1358099-18-9
Purity	>98%
Formula	C26H31N7O
Mol Weight	457.5706
Appearance	Solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Brenke JK, et al. Targeting TRAF6 E3 ligase activity with a small-molecule inhibitor combats autoimmunity. J Biol Chem. 2018 Aug 24;293(34):13191-13203.
CoA	CoA of C25-140

Smiles:	CC1=NN=C2C=CC(=NN12)N1N=C(C)C(CCC(=O)N2CCC(CC3=CC=CC=C3)CC2)=C1C


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