GSK1324726A

GSK1324726A is a novel, potent, and selective inhibitor of BET proteins with high affinity to BRD2 (IC50=41 nM), BRD3 (IC50=31 nM), and BRD4 (IC50=22 nM).


Cat. No.: EX-A2221	Purity: >98%

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	400	In-stock
250mg	685	In-stock
500mg	950	In-stock
1g	1550	In-stock
5g	6200	In-stock
10g	9820	In-stock

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Synonyms	I-BET726
CAS No.	1300031-52-0
Purity	>98%
Formula	C25H23ClN2O3
Mol Weight	434.915
Appearance	solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Wyce A, et al. BET inhibition silences expression of MYCN and BCL2 and induces cytotoxicity in neuroblastoma tumor models. PLoS One. 2013 Aug 23;8(8):e72967. [2]. Gosmini R, et al. The discovery of I-BET726 (GSK1324726A), a potent tetrahydroquinoline ApoA1 up-regulator and selective BET bromodomain inhibitor. J Med Chem. 2014 Oct 9;57(19):8111-31.
CoA	CoA of GSK1324726A

Smiles:	C[C@H]1C[C@@H](NC2=CC=C(Cl)C=C2)C2=C(C=CC(=C2)C2=CC=C(C=C2)C(O)=O)N1C(C)=O


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