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Product Information:

Mitapivat

Mitapivat (AG-348) is an orally active pyruvate kinase allosteric activator. Mitapivat can be used in study of PK deficiency.

Cat. No.: EX-A2626    Purity: >98%
Mitapivat
For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
100mg650In-stock
200mg850In-stock
500mg1150In-stock
1g1575In-stock
5g3885In-stock
10g6585In-stock


SynonymsAG-348
CAS No.1260075-17-9
Purity>98%
FormulaC24H26N4O3S
Mol Weight450.553
AppearanceSolid powder
SolubilityDMSO : 20.83 mg/mL (46.23 mM; ultrasonic and warming and heat to 60°C)
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Kung C, et al. AG-348 enhances pyruvate kinase activity in red blood cells from patients with pyruvate kinase deficiency. Blood. 2017 Sep 14;130(11):1347-1356.

[2]. Matte A, et al. The pyruvate kinase activator mitapivat reduces hemolysis and improves anemia in a β-thalassemia mouse model. J Clin Invest. 2021 May 17;131(10):e144206.

[3]. Rab MAE, et al. AG-348 (Mitapivat), an allosteric activator of red blood cell pyruvate kinase, increases enzymatic activity, protein stability, and ATP levels over a broad range of PKLR genotypes. Haematologica. 2021 Jan 1;106(1):238-249.

CoACoA of Mitapivat
Smiles:O=C(N1CCN(CC2CC2)CC1)C1=CC=C(NS(=O)(=O)C2=C3N=CC=CC3=CC=C2)C=C1

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