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Product Information:

Petesicatib

Petesicatib (RG-7625, RO-5459072) is a cathepsin S inhibitor, used in research of immune diseases.

Cat. No.: EX-A3136    Purity: >98%
Petesicatib
For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
50mg785In-stock
100mg1085In-stock
200mg1585In-stock
500mg2285In-stock
1g3585In-stock
5g11985In-stock


SynonymsRG-7625
Synonyms 2RO-5459072
CAS No.1252637-35-6
Purity>98%
FormulaC25H23F6N5O4S
Mol Weight603.537
Appearancesolid powder
SolubilityDMSO >100mg/mL
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Kratochwil, Nicole A et al. “Population pharmacokinetic analysis of RO5459072, a low water-soluble drug exhibiting complex food-drug interactions.” British journal of clinical pharmacology vol. 87,9 (2021): 3550-3560.

[2]. Hargreaves, Patrick et al. “Differential effects of specific cathepsin S inhibition in biocompartments from patients with primary Sjögren syndrome.” Arthritis research & therapy vol. 21,1 175. 18 Jul. 2019

[3]. Theron, Michel et al. “Pharmacodynamic Monitoring of RO5459072, a Small Molecule Inhibitor of Cathepsin S.” Frontiers in immunology vol. 8 806. 17 Jul. 2017

[4]. Tato, Maia et al. “Cathepsin S inhibition combines control of systemic and peripheral pathomechanisms of autoimmune tissue injury.” Scientific reports vol. 7,1 2775. 5 Jun. 2017

[5]. Rubén Alvarez Sánchez, et al. Novel proline derivatives. US20100267722A1

Data SheetData sheet of Petesicatib
CoACoA of Petesicatib
SDSSDS of Petesicatib
Smiles:O=C(N1[C@@H](C[C@@H](S(=O)(C2=C(C=C(C3=CN(C)N=C3)C=C2)C(F)(F)F)=O)C1)C(NC4(CC4)C#N)=O)C5(CC5)C(F)(F)F

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