Ex 26

Ex26 is a peripherally-restricted biphenylcarboxamide derivative that acts as a highly potent and subtype-selective S1P1 antagonist (IC50 = 0.93 nM against S1PR1 and >3.1 μM against S1PR2/3/4/5).


Cat. No.: EX-A3032	Purity: >98%

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
50mg	700	In-stock
100mg	1100	In-stock
200mg	1800	In-stock
1g	Get quote	In-stock

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Synonyms	Ex26
CAS No.	1233332-37-0
Purity	>98%
Formula	C28H28ClFN2O3
Mol Weight	494.985
Appearance	white to beige powder
Solubility	DMSO: 25 mg/mL, clear
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Teijaro et al (2016) S1PR1-mediated IFNAR1 degradation modulates plasmacytoid dendritic cell IF.-a autoamplification. Proc.Natl.Acad.Sci.U.S.A. 113 1351 PMID: 26787880 [2]. Cahalan et al (2013) Sphingosine 1-phosphate receptor 1 (S1P1) upregulation and amelioration of experimental autoimmune encephalomyelitis by an S1P1 antagonist. Mol.Pharmacol. 83 316 PMID: 23204443
CoA	CoA of Ex 26

Smiles:	CC(NC1=CC(=C(F)C=C1)C1=CC(C)=C(C(=O)NC2(CC2)C(O)=O)C(C)=C1)C1=CC(C)=C(Cl)C=C1


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