LOXO101

Larotrectinib (LOXO-101, ARRY-470) is an oral potent and selective ATP-competitive inhibitor of tropomyosin receptor kinases (TRK). Larotrectinib inhibition of TRKs induces cellular apoptosis and G1 cell-cycle arrest.


Cat. No.: EX-A1981	Purity: 98.72%

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
200mg	500	In-stock
500mg	650	In-stock
1g	850	In-stock
5g	2250	In-stock
10g	3200	In-stock

Send PO to E-mail:order@excenen.com; or Fax:+86 020 81619670

Discount Request


Synonyms	LOXO-101
Synonyms 2	Larotrectinib
CAS No.	1223403-58-4
Purity	98.72%
Formula	C21H22F2N6O2
Mol Weight	428.4352
Appearance	solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Ghilardi JR, et al. Administration of a tropomyosin receptor kinase inhibitor attenuates sarcoma-induced nerve sprouting, neuroma formation and bone cancer pain. Mol Pain. 2010, 6:87. [2]. Vaishnavi A, et al. Oncogenic and drug-sensitive NTRK1 rearrangements in lung cancer. Nat Med. 2013, 19(11):1469-72.
CoA	CoA of LOXO101

Smiles:	O[C@H]1CCN(C1)C(=O)NC1=C2N=C(C=CN2N=C1)N1CCC[C@@H]1C1=CC(F)=CC=C1F


		Search