Product Information:

MLN9708

MLN2238 suppresses the chymotrypsin-like proteolytic (β5) site of the 20S Proteasome(Ki50=0.93 nM, IC50=3.4 nM/). The biologically active form of MLN9708 is MLN2238 in aqueous solutions or plasma.


Cat. No.: EX-A2106	Purity: >98%

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
500mg	550	In-stock
1g	850	In-stock
5g	1880	In-stock
10g	2880	In-stock

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CAS No.	1201902-80-8
Purity	>98%
Formula	C20H23BCl2N2O9
Mol Weight	517.122
Appearance	solid powder
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Kupperman, Erik et al. “Evaluation of the proteasome inhibitor MLN9708 in preclinical models of human cancer.” Cancer research vol. 70,5 (2010): 1970-80. doi:10.1158/0008-5472.CAN-09-2766 [2]. Chauhan, Dharminder et al. “In vitro and in vivo selective antitumor activity of a novel orally bioavailable proteasome inhibitor MLN9708 against multiple myeloma cells.” Clinical cancer research : an official journal of the American Association for Cancer Research vol. 17,16 (2011): 5311-21. doi:10.1158/1078-0432.CCR-11-0476 [3]. Lee, Edmund C et al. “Antitumor activity of the investigational proteasome inhibitor MLN9708 in mouse models of B-cell and plasma cell malignancies.” Clinical cancer research : an official journal of the American Association for Cancer Research vol. 17,23 (2011): 7313-23. doi:10.1158/1078-0432.CCR-11-0636
CoA	CoA of MLN9708

Smiles:	CC(C)C[C@H](NC(=O)CNC(=O)C1=C(Cl)C=CC(Cl)=C1)B1OC(=O)CC(CC(O)=O)(O1)C(O)=O


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