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Product Information:

GDC-0575

GDC-0575 (ARRY-575, RG7741) is a highly-selective oral small-molecule Chk1 inhibitor with an IC50 of 1.2 nM.

Cat. No.: EX-A3129    Purity: >98%
GDC-0575
For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
100mg350In-stock
250mg650In-stock
500mg950In-stock
1g1250In-stock
5g3980In-stock


SynonymsARRY-575
Synonyms 2RG7741
CAS No.1196541-47-5
Purity>98%
FormulaC16H20BrN5O
Mol Weight378.267
AppearanceLight yellow to yellow solid powder
SolubilitySoluble in DMSO
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Oo ZY, et al. Endogenous Replication Stress Marks Melanomas Sensitive to CHEK1 Inhibitors In Vivo. Clin Cancer Res. 2018 Mar 13. doi: 10.1158/1078-0432.CCR-17-2701.

[2]. Laroche-Clary A, et al. CHK1 inhibition in soft-tissue sarcomas: biological and clinical implications. Ann Oncol. 2018 Apr 1;29(4):1023-1029.

[3]. Di Tullio A, et al. The combination of CHK1 inhibitor with G-CSF overrides cytarabine resistance in human acute myeloid leukemia. Nat Commun. 2017 Nov 22;8(1):1679.

CoACoA of GDC-0575
Smiles:O=C(C1CC1)NC2=CNC3=NC=C(Br)C(N4C[C@H](N)CCC4)=C32

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