TAS-115

Pamufetinib (TAS-115) is a potent VEGFR and hepatocyte growth factor receptor (c-Met/HGFR)-targeted kinase inhibitor with IC50s of 30 and 32 nM for rVEGFR2 and rMET, respectively.


Cat. No.: EX-A2850	Purity: >98%

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	750	In-stock
250mg	1150	In-stock
500mg	1750	In-stock
1	g	2400
In-stock5	g	5800

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Synonyms	Pamufetinib
CAS No.	1190836-34-0
Purity	>98%
Formula	C27H23FN4O4S
Mol Weight	518.559
Appearance	solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Fujita H, et al. The novel VEGF receptor/MET-targeted kinase inhibitor TAS-115 has marked in vivo antitumor properties and a favorable tolerability profile. Mol Cancer Ther. 2013 Dec;12(12):2685-96. [2]. Nakade J, et al. Triple inhibition of EGFR, Met, and VEGF suppresses regrowth of HGF-triggered, erlotinib-resistant lung cancer harboring an EGFR mutation. J Thorac Oncol. 2014 Jun;9(6):775-83.
CoA	CoA of TAS-115

Smiles:	CNC(=O)C1=C(OC)C=C2N=CC=C(OC3=CC=C(NC(=S)NC(=O)CC4=CC=CC=C4)C=C3F)C2=C1


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