MRT67307

MRT67307 is a dual inhibitor of the IKKε and TBK-1 with IC50s of 160 and 19 nM, respectively. MRT67307 also inhibits ULK1 and ULK2 with IC50s of 45 and 38 nM, respectively. MRT67307 also blocks autophagy in cells.


Cat. No.: EX-A2799	Purity: >98%

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
250mg	465	In-stock
500mg	700	In-stock
1g	1100	In-stock
2g	1800	In-stock
5g	3800	In-stock
10g	4865	In-stock

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CAS No.	1190378-57-4
Purity	>98%
Formula	C26H36N6O2
Mol Weight	464.603
Appearance	solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Clark K, et al. Novel cross-talk within the IKK family controls innate immunity. Biochem J. 2011 Feb 15;434(1):93-104. [2]. Petherick KJ, et al. Pharmacological inhibition of ULK1 kinase blocks mammalian target of rapamycin (mTOR)-dependent autophagy. J Biol Chem. 2015 May 1;290(18):11376-83.
CoA	CoA of MRT67307

Smiles:	O=C(NCCCNC1=NC(NC2=CC=CC(CN3CCOCC3)=C2)=NC=C1C1CC1)C1CCC1


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