Edicotinib

Edicotinib (JNJ-40346527) is a potent, selective, brain penetrant and orally active colony-stimulating factor-1 receptor (CSF-1R) inhibitor with an IC50 of 3.2 nM.


Cat. No.: EX-A2787	Purity: >98%

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	700	In-stock
250mg	1100	In-stock
500mg	1750	In-stock
1g	2550	In-stock
5g	10200	In-stock

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Synonyms	JNJ-40346527
Synonyms 2	JNJ-527
CAS No.	1142363-52-7
Purity	>98%
Formula	C27H35N5O2
Mol Weight	461.5991
Appearance	Solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Mancuso R, et al. CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice.Brain. 2019 Oct 1;142(10):3243-3264. [2]. Genovese MC, et al. Results from a Phase IIA Parallel Group Study of JNJ-40346527, an Oral CSF-1R Inhibitor, in Patients with Active Rheumatoid Arthritis despite Disease-modifying Antirheumatic Drug Therapy.J Rheumatol. 2015 Oct;42(10):1752-60.
CoA	CoA of Edicotinib

Smiles:	CC1(C)CCC(=CC1)C1=C(NC(=O)C2=NC=C(N2)C#N)C=CC(=N1)C1CC(C)(C)OC(C)(C)C1


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