VER-155008

VER-155008 is an inhibitor of Hsp70, with IC50s of 0.5 μM, 2.6 μM, and 2.6 μM for Hsp70, Hsc70 and Grp7, respectively, and with a Kd of 0.3 μM for Hsp70.


Cat. No.: EX-A2275	Purity: >98%

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
500mg	985	In-stock
1g	1585	In-stock
2g	2650	In-stock
5g	5600	In-stock
10g	8850	In-stock

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CAS No.	1134156-31-2
Purity	>98%
Formula	C25H23Cl2N7O4
Mol Weight	556.401
Appearance	solid powder
Solubility	DMSO : ? 37 mg/mL (66.50 mM)
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Massey AJ, et al. A novel, small molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor induced apoptosis in HCT116 colon carcinoma cells. Cancer Chemother Pharmacol. 2010 Aug;66(3):535-45. [2]. Yang X, et al. Heat Shock Cognate 70 Inhibitor, VER-155008, Reduces Memory Deficits and Axonal Degeneration in a Mouse Model of Alzheimer's Disease. Front Pharmacol. 2018 Jan 30;9:48. [3]. Kita K, et al. Heat shock protein 70 inhibitors suppress androgen receptor expression in LNCaP95 prostate cancer cells. Cancer Sci. 2017 Sep;108(9):1820-1827.
CoA	CoA of VER-155008

Smiles:	NC1=NC=NC2=C1N=C(NCC1=CC=C(Cl)C(Cl)=C1)N2[C@@H]1O[C@H](COCC2=CC=C(C=C2)C#N)[C@@H](O)[C@H]1O


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