JZL184

JZL 184 is a potent, selective and irreversible MAGL inhibitor that blocks 2-Arachidonoylglycerol (2-AG) hydrolysis in brain membranes (IC50 of 8 nM). JZL 184 displays >300-fold selectivity for MAGL over FAAH.


Cat. No.: EX-A2084	Purity: >98%

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
250mg	550	In-stock
500mg	750	In-stock
1g	1100	In-stock
5g	2650	In-stock
10g	3850	In-stock

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Synonyms	JZL-184
Synonyms 2	JZL 184
CAS No.	1101854-58-3
Purity	>98%
Formula	C27H24N2O9
Mol Weight	520.4875
Appearance	solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Long JZ, et al. Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects. Nat Chem Biol. 2009 Jan;5(1):37-44. [2]. Pan B, et al. Blockade of 2-arachidonoylglycerol hydrolysis by selective monoacylglycerol lipase inhibitor 4-nitrophenyl 4-(dibenzo[d][1,3]dioxol-5-yl(hydroxy)methyl)piperidine-1-carboxylate (JZL184) Enhances retrograde endocannabinoid signaling. J Pharmacol Exp Ther. 2009 Nov;331(2):591-7.
CoA	CoA of JZL184

Smiles:	OC(C1CCN(CC1)C(=O)OC1=CC=C(C=C1)[N+]([O-])=O)(C1=CC=C2OCOC2=C1)C1=CC2=C(OCO2)C=C1


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