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Product Information:

SD-36

SD-36 is a PROTAC Degrader of STAT3 Protein (Kd=~50 nM) and demonstrates high selectivity over other STAT members.

Cat. No.: EX-A5026    Purity: >98%
Chemical
Chemical structure of SD-36


For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
5mg1350In-stock
10mg2150In-stock
100mg4350In-stock
200mg6850In-stock
500mg12250In-stock


CAS No.2429877-44-9
Purity>98%
FormulaC59H62F2N9O12P
Mol Weight1158.1472
ColorWhite to off-white
Statesolid powder
SolubilitySoluble in DMSO
Shelf Life>2 years if stored properly
StoragePowder -80°C, stored under nitrogen;
ShippingShipped with dry ice.
 
 
Reference:  1. Zhou H, et al. Structure-Based Discovery of SD-36 as a Potent, Selective, and Efficacious PROTAC Degrader of STAT3 Protein. J Med Chem. 2019 Dec 10.

[2]. Bai L, et al. A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo. Cance
CoACoA of SD-36
Smiles:O=C([C@@H](NC([C@@H]1CC[C@H](CCN(C(CCCCCC#CC2=CC=CC3=C2CN(C4CCC(NC4=O)=O)C3=O)=O)C[C@@H]5NC(C6=CC(C=C(C(F)(P(O)(O)=O)F)C=C7)=C7N6)=O)N1C5=O)=O)CCC(N)=O)NC(C8=CC=CC=C8)C9=CC=CC=C9

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