Sclerotiorin

Sclerotiorin is a reversible and uncompetitive inhibitor against soybean lipoxygenase-1 (LOX-1) (IC50: 4.2 μM). Sclerotiorin also shows antioxidant activity by scavenging free radical (ED50: 0.12 μM), and nonenzymatic lipid peroxidation inhibition activity. Sclerotiorin has antifungal activity, and also inhibits platelet aggregation. Sclerotiorin can be purified from the fermented broth of Penicillium frequentans.


Cat. No.: EX-A10617	Purity: >98%

	Chemical structure of Sclerotiorin

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
10mg	850	In-stock
25mg	1685	In-stock
50mg	2985	In-stock
100mg	4985	In-stock
250mg	get quote	In-stock
500mg	get quote	In-stock

Send PO to E-mail:[email protected]; or Fax:+86 020 81619670

Discount Request


CAS No.	549-23-5
Purity	>98%
Formula	C21H23ClO5
Mol Weight	390.857
State	solid powder
Solubility	DMF: 30 mg/ml, DMF:PBS(pH7.2) (1:2): 0.3 mg/ml, DMSO: 20 mg/ml, Ethanol: 3 mg/ml
Shelf Life	>3 years if stored properly
Storage	Powder -20℃ 3 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Tomoda, H., Matsushima, C., Tabata, N., et al. Structure-specific inhibition of cholesteryl ester transfer protein by azaphilones J. Antibiot. (Tokyo) 52(2),160-170 (1999). [2]. Chidananda, C., and Sattur, A.P. Sclerotiorin, a novel inhibitor of lipoxygenase from Penicillium frequentans J. Agric. Food Chem. 55(8),2879-2883 (2007). [3]. Pairet, L., Wrigley, S.K., Chetland, I., et al. Azaphilones with endothelin receptor binding activity produced by Penicillium sclerotiorum: Taxonomy, fermentation, isolation, structure elucidation and biological activity J. Antibiot. (Tokyo) 48(9),913-923 (1995). [4]. Ji-Youn, N., Son, K.H., Kim, H.K., et al. Sclerotiorin and isochromophilone IV: Inhibitors of Grb2-Shc interaction, isolated from Penicillium multicolor F1753 J. Microbiol. Biotechnol. 10(4),544-546 (2000).
CoA	CoA of Sclerotiorin

Smiles:	O=C1[C@](C)(OC(C)=O)C(C2=COC(/C=C/C(C)=C/[C@@H](C)CC)=CC2=C1Cl)=O


		Search