SC-919

SC-919 (LI-2124) is an orally active IP6K inhibitor, with an IC50 of < 5.2 nM against IP6K1, < 3.8 nM against IP6K2, and 0.65 nM against IP6K3. By inhibiting the activity of IP6K, SC-919 reduces intracellular IP7 levels, thereby suppressing XPR1-mediated cellular phosphate efflux. SC-919 increases intracellular phosphate and ATP levels while reducing phosphate entry into the bloodstream, thus decreasing plasma phosphate levels. SC-919 can be used in research related to chronic kidney disease and hyperphosphatemia.


Cat. No.: EX-A6505	Purity: >98%

	Chemical structure of SC-919

For research only, Do not use for Human!

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CAS No.	2245949-62-4
Purity	>98%
Formula	C19H16Cl2N2O4
Mol Weight	407.247
Color	White to off-white
State	solid powder
Solubility	Soluble in DMSO 50 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20°C 3 years, 4°C 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Moritoh Y, et al. The enzymatic activity of inositol hexakisphosphate kinase controls circulating phosphate in mammals. Nat Commun. 2021;12(1):4847. Published 2021 Aug 11.
CoA	CoA of SC-919


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