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Product Information:

SB-224289 hydrochloride

SB-224289 hydrochloride is a selective 5-HT1B receptor antagonist, with anxiolytic effect.

Cat. No.: EX-A2482A    Purity: >98%
Chemical
Chemical structure of SB-224289 hydrochloride


For research only, Do not use for Human!

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SynonymsSB-224289A
CAS No.180084-26-8
Purity>98%
FormulaC32H33ClN4O3
Mol Weight557.082
ColorWhite to off-white
Statesolid powder
SolubilityDMSO : 4.31 mg/mL H2O : < 0.1 mg/mL
Shelf Life>1 years if stored properly
Storage-20°C, stored under nitrogen, away from moisture
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Cassilly CD, et al. SB-224289 Antagonizes the Antifungal Mechanism of the Marine Depsipeptide Papuamide A. PLoS One. 2016 May 16;11(5):e0154932.

[2]. Hoplight BJ, et al. The effects of SB 224289 on anxiety and cocaine-related behaviors in a novel object task. Physiol Behav. 2005 Apr 13;84(5):707-14. Epub 2005 Apr 13.

[3]. Gaster LM, et al. The selective 5-HT1B receptor inverse agonist SB-224289, potently blocks terminal 5-HT autoreceptor function both in vitro and in vivo. Ann N Y Acad Sci. 1998 Dec 15;861:270-1.

CoACoA of SB-224289 hydrochloride
Smiles:O=C(C1=CC=C(C2=CC=C(C3=NOC(C)=N3)C=C2C)C=C1)N4CCC5=C4C=C6C(OCC67CCN(C)CC7)=C5.Cl

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