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Product Information:

SARM1-IN-2

SARM1-IN-2 (Example 82) is a SARM1 inhibitor (IC50 <1 μM) that inhibits axon regeneration. Axon regeneration refers to the process by which neuronal axons attempt to restore their structure and function after axonal degeneration. SARM1-IN-2 inhibits axon regeneration by reducing or inhibiting the binding of SARM1 to NAD+. SARM1-IN-2 can be used to study axonal degeneration .

Cat. No.: EX-A10301    Purity: >98%
Chemical
Chemical structure of SARM1-IN-2


For research only, Do not use for Human!

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CAS No.2396592-52-0
Purity>98%
FormulaC16H14N4O2S
Mol Weight326.373
ColorLight yellow to yellow
StateSolid
SolubilitySoluble in DMSO
Shelf Life>3 years if stored properly
StoragePowder -20℃ 3 years, 4℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Bonneau N, et al. Assessment of corneal nerve regeneration after axotomy in a compartmentalized microfluidic chip model with automated 3D high resolution live-imaging. Front Cell Neurosci. 2024 Jul 15;18:1417653.

[2]. Hughes RO, et, al. Inhibitors of sarm1. WO2019236890A1.

CoACoA of SARM1-IN-2
Smiles:N#CC1=C(NC2=C3C=CC(C)=NC3=CC=C2OC)SN(C)C1=O

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