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Product Information:

SAR439859

SAR439859 (compound 43d) is an orally available and nonsteroidal selective estrogen receptor degrader (SERD) with potential antineoplastic activity.

Cat. No.: EX-A4678    Purity: >98%
Chemical
Chemical structure of SAR439859


For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
100mg850In-stock
250mg1350In-stock
500mg2150In-stock
1g3300In-stock
2g5800In-stock
5g11550In-stock


SynonymsAmcenestrant
CAS No.2114339-57-8
Purity>98%
FormulaC31H30Cl2FNO3
Mol Weight554.479
Statesolid powder
SolubilitySoluble in DMSO
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  [1]. El-Ahmad Y, et al. Discovery of 6-(2,4-Dichlorophenyl)-5-[4-[(3S)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8, 9-dihydro-7H-benzo[7]annulene-2-carboxylic acid (SAR439859), a Potent and Selective Estrogen Receptor Degrader (SERD) for the Treatment of Estrogen-Receptor-Positive Breast Cancer. J Med Chem. 2019 Nov 27. doi: 10.1021/acs.jmedchem.9b01293. [Epub ahead of print] PubMed PMID: 31721572.

[2]. Monsif Bouaboula, et al. Abstract 943: SAR439859, an orally bioavailable selective estrogen receptor degrader (SERD) that demonstrates robust antitumor efficacy and limited cross-resistance in ER+ breast cancer.
CoACoA of SAR439859
Smiles:C1CC2=C(C=CC(=C2)C(=O)O)C(=C(C1)C3=C(C=C(C=C3)Cl)Cl)C4=CC=C(C=C4)O[C@H]5CCN(C5)CCCF

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