SAR405

SAR405 is a first-in-class, selective, and ATP-competitive PI3K class III (PIK3C3) isoform Vps34 inhibitor (IC50=1.2 nM; Kd=1.5 nM). SAR405 inhibits autophagy induced either by starvation or by mTOR inhibition. Anticancer activity .


Cat. No.: EX-A2522	Purity: >98%

	Chemical structure of SAR405

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	650	In-stock
250mg	1085	In-stock
250mg	1550	In-stock
1g	2450	In-stock
5g	get quote	In-stock

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CAS No.	1523406-39-4
Purity	>98%
Formula	C19H21ClF3N5O2
Mol Weight	443.851
Color	off-white to light yellow
State	solid
Solubility	Soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder 4℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Ronan B, et al. A highly potent and selective Vps34 inhibitor alters vesicle trafficking and autophagy. Nat Chem Biol. 2014 Dec;10(12):1013-9. [2]. Pasquier B. SAR405, a PIK3C3/Vps34 inhibitor that prevents autophagy and synergizes with MTOR inhibition in tumor cells. Autophagy. 2015 Apr 3;11(4):725-6.
CoA	CoA of SAR405

Smiles:	C[C@@H]1COCCN1C1=CC(=O)N2CC[C@H](N(CC3=CC(Cl)=CN=C3)C2=N1)C(F)(F)F


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