SANDOZ 58-035

Sandoz 58-035 is a selective acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor. Sandoz 58-035 inhibits this enzyme in intact cells and isolated microsomal fractions. Sandoz 58-035 blocks the esterification of exogenous vesicle-derived cholesterol and the incorporation of oleic acid into cellular cholesterol esters, reducing the formation and accumulation of cholesterol esters. Sandoz 58-035 causes a slight increase in cellular free cholesterol, and at high concentrations, it also causes a slight reduction in overall cellular protein synthesis. Sandoz 58-035 can be used in studies related to cellular cholesterol regulation .


Cat. No.: EX-A9045F	Purity: >99%

	Chemical structure of SANDOZ 58-035

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
5mg	188	In-stock
10mg	312	In-stock
25mg	615	In-stock
50mg	985	In-stock
100mg	1550	In-stock
250mg	get quote	In-stock

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CAS No.	78934-83-5
Purity	>99%
Formula	C30H47NOSi
Mol Weight	465.7858
Color	White to off-white
State	solid
Solubility	Soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder -20℃ 3 years, 4℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Slotte JP. Intracellular processing of exogenously derived non-lipoprotein [3H]cholesterol in normal and mutant human skin fibroblasts deficient in acid sterol ester hydrolase. Biochim Biophys Acta. 1987 Feb 14;917(2):231-7. [2]. Ross AC, et al. Selective inhibition of acyl coenzyme A:cholesterol acyltransferase by compound 58-035. J Biol Chem. 1984;259(2):815-819.
CoA	CoA of SANDOZ 58-035


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