SAK3

SAK3 is a potent T-type voltage-gated Ca2+ channels (T-VGCCs) enhancer. SAK3 enhances Cav3.1 and Cav3.3 T-type Ca2+ channel currents. Acute SAK3 administration improves memory deficits in olfactory-bulbectomized mice[1]. SAK3 inhibits amyloid β plaque formation in APP-KI mice by activating the proteasome activity[2].


Cat. No.: EX-A14653	Purity: >98%

	Chemical structure of SAK3

For research only, Do not use for Human!

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CAS No.	1256269-87-0
Purity	>98%
Formula	C20H23N3O4
Mol Weight	369.4143
Color	White to yellow
State	Solid
Solubility	soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder -20℃, 3 years; 4℃, 2 years; In solvent -20℃, 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Yasushi Yabuki, et al. Pharmacological properties of SAK3, a novel T-type voltage-gated Ca²⁺ channel enhancer. Neuropharmacology. 2017 May 1;117:1-13. [2]. Jing Xu, et al.T-Type Ca²⁺ Enhancer SAK3 Activates CaMKII and Proteasome Activities in Lewy Body Dementia Mice Model. Int J Mol Sci. 2021 Jun 8;22(12):6185.
CoA	CoA of SAK3

Smiles:	CCOC(=O)C1=C(C2(CC1=O)C(=O)N=C3N2C=CC=C3C)N4CCCCC4


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