SAGE-547

Allopregnanolone (Brexanolone, SAGE-547) is an analytical reference standard categorized as a GABAA and GABAC receptor positive allosteric modulator. Allopregnanolone has anxiolytic-like and anticonvulsant activities in rodents.


Cat. No.: EX-A1195	Purity: >99%

	Chemical structure of SAGE-547

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
250mg	550	In-stock
250mg	600	In-stock
1g	700	In-stock
5g	985	In-stock
10g	1585	In-stock

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Synonyms	Brexanolone
Synonyms 2	Allopregnanolone
CAS No.	516-54-1
Purity	>99%
Formula	C21H34O2
Mol Weight	318.4935
State	solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Alvarez LD, Pecci A, Estrin DA. In Search of GABAA Receptor's Neurosteroid Binding Sites. J Med Chem. 2019;62(11):5250-5260. doi:10.1021/acs.jmedchem.8b01400 [2]. Johnston GA, Chebib M, Hanrahan JR, Mewett KN. Neurochemicals for the investigation of GABA(C) receptors. Neurochem Res. 2010;35(12):1970-1977. doi:10.1007/s11064-010-0271-7 [3]. Fernández-Guasti A, Picazo O. Flumazenil blocks the anxiolytic action of allopregnanolone. Eur J Pharmacol. 1995;281(1):113-115. doi:10.1016/0014-2999(95)00311-8 [4]. Reddy DS, Castaneda DC, O'Malley BW, Rogawski MA. Anticonvulsant activity of progesterone and neurosteroids in progesterone receptor knockout mice. J Pharmacol Exp Ther. 2004;310(1):230-239. doi:10.1124/jpet.104.065268
CoA	CoA of SAGE-547

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