S1QEL

S1QEL1.1 is a small molecule inhibitor that specifically inhibits the generation of superoxide and hydrogen peroxide at the IQ site during reverse electron transfer in mitochondrial respiratory chain complex I (Complex I), with an IC50 of 0.07 μM. S1QEL1.1 can significantly reduce the activation of cysteine-aspartic protease (caspase) triggered by endoplasmic reticulum stress. S1QEL1.1 helps to decrease excessive proliferation of stem cells by inhibiting the Reactive Oxygen Species signaling pathway initiated by endoplasmic reticulum stress.


Cat. No.: EX-A11274	Purity: >98%

	Chemical structure of S1QEL

For research only, Do not use for Human!

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CAS No.	897613-29-5
Purity	>98%
Formula	C23H24N4O3S
Mol Weight	436.527
Color	White to off-white
State	solid
Solubility	DMSO : 12.5 mg/mL DMF : 3 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20℃ 3 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Martin D Brand, et al. Suppressors of Superoxide-H2O2 Production at Site IQ of Mitochondrial Complex I Protect against Stem Cell Hyperplasia and Ischemia-Reperfusion Injury. Cell Metab. 2016 Oct 11;24(4):582-592.
CoA	CoA of S1QEL

Smiles:	O=C(NC1=CC=CC(=C1)NC(=O)C)C(=O)NCCC=2SC(=NC2C)C=3C=CC(=CC3)C


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