(S)-Rolipram

(S)-(+)-Rolipram ((+)-Rolipram) is a cyclic AMP(cAMP)-specific phosphodiesterase 4 (PDE4) inhibitor, with an IC50 of 1100 nM. (S)-(+)-Rolipram can suppresse tumor necrosis factor-alpha (TNFα) production by human mononuclear cells .


Cat. No.: EX-A11435	Purity: >98%

	Chemical structure of (S)-Rolipram

For research only, Do not use for Human!

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Synonyms	(S)-(+)-Rolipram
Synonyms 2	(+)-Rolipram;
CAS No.	85416-73-5
Purity	>98%
Formula	C16H21NO3
Mol Weight	275.3428
Color	Off-white to light yellow
State	Solid
Solubility	DMSO : 100 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20℃ 3 years; 4℃, 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Semmler J, et, al. The specific type IV phosphodiesterase inhibitor rolipram suppresses tumor necrosis factor-alpha production by human mononuclear cells. Int J Immunopharmacol. 1993 Apr;15(3):409-13. [2]. Wachtel H. Neurotropic effects of the optical isomers of the selective adenosine cyclic 3',5'-monophosphate phosphodiesterase inhibitor rolipram in rats in-vivo. J Pharm Pharmacol. 1983 Jul;35(7):440-4. [3]. Ortmann R, et, al. Rolipram forms a potent discriminative stimulus in drug discrimination experiments in rats. Psychopharmacology (Berl). 1986;89(3):273-7.
CoA	CoA of (S)-Rolipram

Smiles:	O=C1NC[C@H](C2=CC=C(OC)C(OC3CCCC3)=C2)C1


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