(S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine

(S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine is a dual-targeting PROTAC molecule. (S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine not only targets the ubiquitination and degradation of Smad3, but also elevates the protein level of HIF-α, thereby exerting multi-pathway anti-fibrotic and renoprotective effects. (S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine can be used in a wide range of tumor studies including cancers with KRAS inhibitor resistance, covering pancreatic ductal adenocarcinoma, acute myeloid leukemia, and various soft tissue sarcomas (such as fibrosarcoma, liposarcoma, chondrosarcoma, etc.). (S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine can also be applied to research related to various solid tumors and hematological malignancies, involving multiple cancer types such as colon cancer, breast cancer, ovarian cancer, non-small cell lung cancer, glioblastoma, and melanoma .


Cat. No.: EX-A17488	Purity: >98%

	Chemical structure of (S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
50mg	608	in_stock
100mg	982	in_stock
250mg	1967	in_stock
500mg	3122	in_stock
1g	5072	in_stock
2g	7968	in_stock

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CAS No.	2347517-69-3
Purity	>98%
Formula	C41H46N6O6S
Mol Weight	750.906
Color	White to light yellow
State	Solid
Solubility	DMSO : ? 170 mg/mL
Shelf Life	>3 years if stored properly
Storage	4°C, sealed storage, away from moisture and light
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1].Pingping Hou, et al. Compositions and methods for use in kras-targeted therapies for the treatment of cancer. US20250339520A1. 2025-05-01.
CoA	CoA of (S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine

Smiles:	O=C(N1[C@@H](C[C@H](C1)O)C(N[C@H](C2=CC=C(C3=C(N=CS3)C)C=C2)C)=O)[C@H](C(C)(C)C)NC(CCC(NC(C4=CN=CC=C4)C5=CC6=CC=CC=C6O5)=O)=O


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