S-Me-DM4

S-Me-DM4 is a metabolite of DM4 S-methylated by intracellular enzyme. DM4 is a microtubule-depolymerizing maytansinoid with strong cytotoxicity. DM4 can be used as an ADC Cytotoxin molecule.


Cat. No.: EX-A12335	Purity: >98%

	Chemical structure of S-Me-DM4

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
1mg	330	in_stock
5mg	725	in_stock
10mg	1148	in_stock
25mg	2176	in_stock
50mg	3592	in_stock
100mg	5693	in_stock

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CAS No.	890654-03-2
Purity	>98%
Formula	C39H56ClN3O10S
Mol Weight	794.394
Color	White to off-white
State	Solid
Solubility	DMSO : 100 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20°C, protect from light, stored under nitrogen; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Widdison W, et al. Metabolites of antibody-maytansinoid conjugates: characteristics and in vitro potencies. Mol Pharm. 2015 Jun 1;12(6):1762-73.
CoA	CoA of S-Me-DM4

Smiles:	C[C@]12[C@@](O1)([C@H](C)[C@@]3(C[C@](O)([C@H](OC)/C=C/C=C(\C)/CC4=CC(N(C)C(=O)C[C@@H]2OC([C@@H](N(C(CCC(SC)(C)C)=O)C)C)=O)=C(Cl)C(OC)=C4)NC(=O)O3)[H])[H]


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