(S)-JDQ-443

(S)-JDQ-443 is an isomer of JDQ-443. JDQ-443 is an orally active, potent, selective, and covalent KRAS G12C inhibitor (extracted from patent WO2021120890A1). JDQ-443 shows antitumor activity.


Cat. No.: EX-A5693A	Purity: >98%

	Chemical structure of (S)-JDQ-443

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
10mg	460	in_stock
25mg	878	in_stock
50mg	1307	in_stock
100mg	1908	in_stock
250mg	2877	in_stock
500mg	4008	in_stock

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Synonyms	(S)-NVP-JDQ443
CAS No.	2653994-10-4
Purity	>98%
Formula	C29H28ClN7O
Mol Weight	526.032
Color	Off-white to light yellow
State	solid powder
Solubility	DMSO : 100 mg/mL
Shelf Life	>2 years if stored properly
Storage	Powder -20°C, 3 years , 4°C, 2 years ; In solvent -20°C, 1 month
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. LIU BO, et al. PYRAZOLYL DERIVATIVES USEFUL AS ANTI-CANCER AGENTS. Patent WO2021120890A1. [2]. Weiss A, Lorthiois E, Barys L, et al. Discovery, Preclinical Characterization, and Early Clinical Activity of JDQ443, a Structurally Novel, Potent and Selective, Covalent Oral Inhibitor of KRASG12C. Cancer Discov. 2022;candisc.0158.2022.
CoA	CoA of (S)-JDQ-443

Smiles:	O=C(N1CC2(CC(C2)N3N=C([C@@]([C@@]4=C(Cl)C(C)=CC5=C4C=NN5)=C3C)C6=CC=C7C(C=NN7C)=C6)C1)C=C


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