S-600918

Sivopixant (S-600918) is a potent and selective P2X3 receptor antagonist (P2X3 IC50=4.2 nM; P2X2/3 IC50=1100 nM). Sivopixant shows strong analgesic effect.


Cat. No.: EX-A5402	Purity: >98%

	Chemical structure of S-600918

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
25mg	370	in_stock
50mg	546	in_stock
100mg	746	in_stock
250mg	1171	in_stock
500mg	1658	in_stock
1g	2352	in_stock

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Synonyms	Sivopixant
CAS No.	2414285-40-6
Purity	>98%
Formula	C25H22ClN5O5
Mol Weight	507.926
Color	White to off-white
State	solid powder
Solubility	Soluble in DMSO 12.5 mg/mL
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Kai H, et al. Discovery of clinical candidate Sivopixant (S-600918): Lead optimization of dioxotriazine derivatives as selective P2X3 receptor antagonists [published online ahead of print, 2021 Sep 26]. Bioorg Med Chem Lett. 2021;52:128384.
CoA	CoA of S-600918

Smiles:	O=C([C@H](CN1C(N(/C(NC1=O)=N/C2=CC=C(C=C2)OC3=NC=CC=C3)CC4=CC=C(C=C4)Cl)=O)C)O


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