S-18986

S 18986 is a selective, orally active, brain penetrant positive allosteric modulator of AMPA-type receptors. S 18986 shows cognitive enhancing properties in rodents.


Cat. No.: EX-A818	Purity: >98%

	Chemical structure of S-18986

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
50mg	785	In-stock
100mg	1185	In-stock
250mg	2585	In-stock
500mg	4285	In-stock
1g	6850	In-stock

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CAS No.	175340-20-2
Purity	>98%
Formula	C10H12N2O2S
Mol Weight	224.279
State	solid powder
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Bernard K, et al. DRUG FOCUS: S 18986: A positive allosteric modulator of AMPA-type glutamate receptorspharmacological profile of a novel cognitive enhancer. CNS Neurosci Ther. 2010 Oct;16(5):e193-212. [2]. Bourasset F, et al. Neuropharmacokinetics of a new alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) modulator, S18986 [(S)-2,3-dihydro-[3,4]cyclopentano-1,2,4-benzothiadiazine-1,1-dioxide], in the rat. Drug Metab Dispos. 2005 Aug;33(8):113
CoA	CoA of S-18986

Smiles:	[H][C@]12CCCN1C1=CC=CC=C1S(=O)(=O)N2


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