RX-518

Olafertinib is a third-generation EGFR TKI, with GI50 values of 5 nM (EGFR L858R/T790M), 10 nM (EGFR del19) and 689 nM (EGFR WT), respectively. Olafertinib has the potential for NSCLC research.


Cat. No.: EX-A1142	Purity: >98%

	Chemical structure of RX-518

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
1g	425	In-stock
2g	685	In-stock
5g	1385	In-stock
10g	2218	In-stock

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Synonyms	Olafertinib
CAS No.	1660963-42-7
Purity	>98%
Formula	C29H28F2N6O2
Mol Weight	530.5684
Color	light yellow to yellow
State	solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 3 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Misako Nagasaka, et al. Beyond osimertinib: The development of 3 rd-generation EGFR Tyrosine Kinase Inhibitors. J Thorac Oncol. 2020 Dec 15;S1556-0864(20)31105-9.
CoA	CoA of RX-518

Smiles:	OCCN1CCN(CC1)C1=CC=C(NC2=NC=C3C=CC=C(C4=CC(NC(=O)C=C)=CC=C4)C3=N2)C(F)=C1F


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