RTI-7470-44

RTI-7470-44 is a potent, selective and blood-brain barrier (BBB) penetrant human trace amine-associated receptor subtype 1 (hTAAR1) antagonist with an IC50 value of 8.4 nM and a Ki value of 0.3 nM. RTI-7470-44 has moderate metabolic stability, and a favorable preliminary off-target profile. RTI-7470-44 can increase the spontaneous firing rate of mouse ventral tegmental area (VTA) dopaminergic neurons. RTI-7470-44 can be used for researching schizophrenia, agent addiction, and Parkinson's disease (PD) .


Cat. No.: EX-A11787	Purity: >98%

	Chemical structure of RTI-7470-44

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
50mg	700	In-stock
100mg	1050	In-stock
250mg	1650	In-stock
500mg	2550	In-stock
1g	4250	In-stock
5g	get quote	In-stock

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CAS No.	825658-63-7
Purity	>98%
Formula	C19H11ClF3N5OS
Mol Weight	449.837
Color	Off-white to light yellow
State	solid
Solubility	Soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder 4℃, 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Decker AM, et al. Identification of a Potent Human Trace Amine-Associated Receptor 1 Antagonist. ACS Chem Neurosci. 2022 Apr 6;13(7):1082-1095.
CoA	CoA of RTI-7470-44

Smiles:	C1=CN=C(N=C1)NC(=O)CSC2=C(C(=CC(=N2)C3=CC=C(C=C3)Cl)C(F)(F)F)C#N


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