RP101988

RP101988, the major active metabolite of Ozanimod, is a selective, potent S1PR1 (sphingosine-1-phosphate receptor 1) agonist, with EC50s of 0.19 nM and 32.8 nM for S1PR1 and S1PR5, respectivlely.


Cat. No.: EX-A8509C	Purity: 98.99%

	Chemical structure of RP101988

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
5mg	360	In-stock
10mg	578	In-stock
25mg	1080	In-stock
50mg	1660	In-stock
100mg	2350	In-stock
200mg	3520	In-stock

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CAS No.	2990018-57-8
Purity	98.99%
Formula	C23H22N4O4
Mol Weight	418.4452
Color	Off-white to light yellow
State	solid powder
Solubility	DMSO : 125 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20°C, 3 years , 4°C, 2 years ; In solvent -20°C, 1 year
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Tran JQ, et al. Cardiac Safety of Ozanimod, a Novel Sphingosine-1-Phosphate Receptor Modulator: Results of a Thorough QT/QTc Study. Clin Pharmacol Drug Dev. 2018;7(3):263-276. [2]. Gilardi D, et al. PK, PD, and interactions: the new scenario with JAK inhibitors and S1P receptor modulators, two classes of small molecule drugs, in IBD [published online ahead of print, 2020 Jul 1]. Expert Rev Gastroenterol Hepatol. 2020;1-10.
CoA	CoA of RP101988

Smiles:	O=C(O)CN[C@H]1CCC2=C1C=CC=C2C3=NOC(C4=CC=C(OC(C)C)C(C#N)=C4)=N3


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