ROS-generating agent 1

ROS-generating agent 1 (Compound 2c) covalently modifies the Sec-498 residue of TrxR to generate ROS. ROS-generating agent 1 reduces intracellular TrxR protein level. ROS-generating agent 1 results in ROS-dependent apoptosis and ferroptosis of NCI-H460 cells. ROS-generating agent 1 has anti-cancer activities.


Cat. No.: EX-A7881	Purity: >98%

	Chemical structure of ROS-generating agent 1

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
5mg	485	In-stock
10mg	685	In-stock
25mg	1085	In-stock

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CAS No.	2369030-41-9
Purity	>98%
Formula	C21H15F6NO
Mol Weight	411.3403
Color	Light yellow to yellow
State	solid powder
Solubility	DMSO : 33.33 mg/mL
Shelf Life	>2 years if stored properly
Storage	Powder -20°C, 3 years , 4°C, 2 years ; In solvent -20°C, 1 month
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Liu X, et al. Tumor killing by a dietary curcumin mono-carbonyl analog that works as a selective ROS generator via TrxR inhibition. Eur J Med Chem. 2023 Mar 15;250:115191.
CoA	CoA of ROS-generating agent 1

Smiles:	O=C1/C(CNC/C1=C\C2=CC(C(F)(F)F)=CC=C2)=C/C3=CC=CC(C(F)(F)F)=C3


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