Rolapitant hydrochloride monohydrate

Rolapitant hydrochloride hydrate (SCH619734 hydrochloride hydrate) is a potent, selective, long-acting and orally active neurokinin 1 (NK1) receptor antagonist with a Ki of 0.66 nM. Rolapitant hydrochloride hydrate does not interact with CYP3A4. Rolapitant hydrochloride hydrate shows potent anti-emetic activity in a ferret emesis model.


Cat. No.: EX-A1288A	Purity: >99.5%

	Chemical structure of Rolapitant hydrochloride monohydrate

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	340	In-stock
250mg	670	In-stock
500mg	1050	In-stock
1g	1680	In-stock
2g	2600	In-stock
3g	3298	In-stock

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Synonyms	SCH619734 hydrochloride hydrate
CAS No.	914462-92-3
Purity	>99.5%
Formula	C25H29ClF6N2O3
Mol Weight	554.953
Color	White to off-white
State	solid powder
Solubility	DMSO : 250 mg/mL
Shelf Life	>1 years if stored properly
Storage	4°C, protect from light, stored under nitrogen
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Duffy RA, et al. Rolapitant (SCH 619734): a potent, selective and orally active neurokininNK1 receptor antagonist with centrally-mediated antiemetic effects inferrets. Pharmacol Biochem Behav. 2012 Jul;102(1):95-100. [2]. Rapoport B, et al. Study of rolapitant, a novel, long-acting, NK-1 receptor antagonist, for the prevention of chemotherapy-induced nausea and vomiting (CINV) due to highly emetogenic chemotherapy (HEC). Support Care Cancer. 2015 Nov;23(11):3281-8.
CoA	CoA of Rolapitant hydrochloride monohydrate


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