Rodatristat ethyl

Rodatristat ethyl (KAR5585) is a first-in-class oral tryptophan hydroxylase 1 (TPH1) Inhibitor with nanomolar in vitro potency. Rodatristat ethyl reduces the level of 5-HT and significantly reduces pulmonary arterial hypertension (PAH).


Cat. No.: EX-A5965A	Purity: 98+%

	Chemical structure of Rodatristat ethyl

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
5mg	724	in_stock
10mg	1035	in_stock
25mg	1840	in_stock
50mg	2926	in_stock
100mg	3880	in_stock

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Synonyms	KAR5585
CAS No.	1673571-51-1
Purity	98+%
Formula	C29H31ClF3N5O3
Mol Weight	590.036
Color	White to off-white
State	solid powder
Solubility	DMSO : 100 mg/mL
Shelf Life	>2 years if stored properly
Storage	Powder -20°C, 3 years , 4°C, 2 years ; In solvent -20°C, 1 month
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Aiello RJ, et al. Tryptophan hydroxylase 1 Inhibition Impacts Pulmonary Vascular Remodeling in Two Rat Modelsof Pulmonary Hypertension. J Pharmacol Exp Ther. 2017 Feb;360(2):267-279. [2]. Alice Melão, MSc. Early Results on Rodatristat Ethyl Support Launch of Phase 2 Trial in PAH Patients. FEBRUARY 4, 2019.
CoA	CoA of Rodatristat ethyl

Smiles:	ClC1=CC(C2=CC=CC=C2)=C([C@@H](OC3=NC(N)=NC(N4CCC5(CN[C@H](C(OCC)=O)C5)CC4)=C3)C(F)(F)F)C=C1


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