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Product Information:

ROCK2-IN-12

ROCK2-IN-12 (Compound A25) is a selective ROCK2 inhibitor with an IC50 of 7.0  nM for ROCK2 over ROCK1. ROCK2-IN-12 has potent antifibrotic effects via the TGF-β/Smad and ROCK2/STAT3 signaling pathways. ROCK2-IN-12 significantly reduces collagen deposition and reverses fibrotic progression in Bleomycin -induced pulmonary fibrosis (PF) mouse models. ROCK2-IN-12 can be used for lung diseases like pulmonary fibrosis research.

Cat. No.: EX-A16321    Purity: >98%
Chemical
Chemical structure of ROCK2-IN-12


For research only, Do not use for Human!

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CAS No.3086603-12-2
Purity>98%
FormulaC23H18FN9O
Mol Weight455.4471
ColorWhite to light yellow
StateSolid
Solubilitysoluble in DMSO
Shelf Life>3 years if stored properly
StoragePowder -20℃ 3 years, 4℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Cao Z, et al. Identification of Novel Imidazo[1,2-b]pyridazine Derivatives as Selective ROCK2 Inhibitors for the Treatment of Pulmonary Fibrosis. J Med Chem. 2025 Oct 23;68(20):21892-21916.

CoACoA of ROCK2-IN-12
Smiles:FC(C=C1)=CC=C1CNCC2=NC(C3=CN=C4C=CC(NC5=CC6=C(C=C5)NN=C6)=NN43)=NO2

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