Ro 67-4853

Ro 67-4853 is a positive allosteric modulator (PAM) of mGluR1 (pEC50=7.16 for rmGlu1a receptor). Ro67-4853 exhibits activity at all group I mGlu receptors including hmGlu1, rmGlu1, and rmGlu5. Ro 67-4853 enhances the potency of L-Glu by interacting with the transmembrane domain (TMD) of the receptor. Ro 67-4853 potentiates sensory synaptic responses to repetitive vibrissa stimulation[1][2][3][4].


Cat. No.: EX-A14586	Purity: >98%

	Chemical structure of Ro 67-4853

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
250mg	550	Inquire
500mg	880	Inquire
1g	1380	Inquire

Send PO to E-mail:[email protected]; or Fax:+86 020 81619670

Discount Request


CAS No.	302841-89-0
Purity	>98%
Formula	C19H19NO4
Mol Weight	325.3585
Color	White to off-white
State	Solid
Shelf Life	>3 years if stored properly
Storage	Powder -20°C, sealed storage, away from moisture and light; In solvent -20°C, 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Knoflach F, et al. Positive allosteric modulators of metabotropic glutamate 1 receptor: characterization, mechanism of action, and binding site [published correction appears in Proc Natl Acad Sci U S A 2001 Dec 18;98(26):15393]. Proc Natl Acad Sci U S A. [2]. Jiang JY, et al. Extracellular calcium modulates actions of orthosteric and allosteric ligands on metabotropic glutamate receptor 1α. J Biol Chem. 2014;289(3):1649-1661. [3]. Salt TE, et al. Potentiation of sensory responses in ventrobasal thalamus in vivo via selective modulation of mGlu1 receptors with a positive allosteric modulator. Neuropharmacology. 2012;62(4):1695-1699. [4]. Sheffler DJ, et al. Allosteric potentiators of metabotropic glutamate receptor subtype 1a differentially modulate independent signaling pathways in baby hamster kidney cells. Neuropharmacology. 2008;55(4):419-427.
CoA	CoA of Ro 67-4853

Smiles:	CCCCOC(=O)NC(=O)C1C2=CC=CC=C2OC3=CC=CC=C13


		Search