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Product Information:

RMC-4630

RMC-4630 is a potent and selective inhibitor of SHP2, a central node in the RAS signaling pathway.

Cat. No.: EX-A5486    Purity: >98%
Chemical
Chemical structure of RMC-4630


For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
50mg350In-stock
100mg585In-stock
250mg885In-stock
500mg1450In-stock
1g2250In-stock
5g6860In-stock


SynonymsSHP2-IN-7
Synonyms 2Vociprotafib
CAS No.2172652-48-9
Purity>98%
FormulaC20H27ClN6O2S
Mol Weight450.985
ColorOff-white to yellow
Statesolid powder
SolubilitySoluble in DMSO 50 mg/mL
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. WO2018013597

[2]. Ou S I, et al. A12 the SHP2 inhibitor RMC-4630 in patients with KRAS-mutant non-small cell lung cancer: preliminary evaluation of a first-in-man phase 1 clinical trial[J]. Journal of Thoracic Oncology, 2020, 15(2): S15-S16.

[3]. Smith J A, et al. SHP2 inhibition as the backbone of targeted therapy combinations for the treatment of cancers driven by oncogenic mutations in the RAS pathway[J]. Cancer Research, 2020, 80(16_Supplement): 1943-1943.

CoACoA of RMC-4630
Smiles:OCC1=NC(SC2=C(Cl)C(N)=NC=C2)=C(C)N=C1N(CC3)CCC43[C@H](N)[C@H](C)OC4

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