RLX-33

RLX-33 is a potent, selective and blood-brain barrier (BBB) penetrant relaxin family peptide 3 (RXFP3) antagonist, also blocks relaxin-3-induced ERK1/2 phosphorylation, with IC50 values of 2.36 μM for RXFP3, 7.82 and 13.86 μM for ERK1 and ERK2 phosphorylation, respectively. RLX-33 can block the stimulation of food intake induced by the RXFP3-selective agonist R3/I5 in rats. RLX-33 can be used for the research of metabolic syndrome.


Cat. No.: EX-A6984	Purity: >98%

	Chemical structure of RLX-33

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
50mg	500	In-stock
100mg	650	In-stock
250mg	1100	In-stock
500mg	1600	In-stock
1g	2200	In-stock
2g	3800	In-stock

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CAS No.	2784577-71-3
Purity	>98%
Formula	C24H19ClN4O4
Mol Weight	462.885
Color	White to light yellow
State	solid powder
Solubility	Soluble in DMSO 125 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20℃ 3 years, 4°C 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Gay, Elaine A et al. “Discovery and Characterization of the First Nonpeptide Antagonists for the Relaxin-3/RXFP3 System.” Journal of medicinal chemistry vol. 65,11 (2022): 7959-7974.
CoA	CoA of RLX-33


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