RKI 1447 dihydrochloride

RKI 1447 dihydrochloride is a potent and selective ROCK inhibitor with IC50s of 14.5 and 6.2 nM for ROCK1 and ROCK2, respectively[1]. RKI 1447 dihydrochloride suppresses colorectal carcinoma cell growth and promotes apoptosis.


Cat. No.: EX-A6761	Purity: >98%

	Chemical structure of RKI 1447 dihydrochloride

For research only, Do not use for Human!

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CAS No.	1782109-09-4
Purity	>98%
Formula	C16H16Cl2N4O2S
Mol Weight	399.295
Color	Off-white to light yellow
State	solid powder
Solubility	Soluble in DMSO 50 mg/mL H2O< 0.1 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder 4°C, sealed storage, away from moisture and light; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Ronil A Patel, et al. RKI-1447 Is a Potent Inhibitor of the Rho-associated ROCK Kinases With Anti-Invasive and Antitumor Activities in Breast Cancer. Cancer Res. 2012 Oct 1;72(19):5025-34. [2]. Liyi Li, et al. RKI-1447 Suppresses Colorectal Carcinoma Cell Growth via Disrupting Cellular Bioenergetics and Mitochondrial Dynamics. J Cell Physiol. 2020 Jan;235(1):254-266.
CoA	CoA of RKI 1447 dihydrochloride


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